Welcome to
FLAP
Future Live Attenuated vaccines in the Pirbright institute
Profiling the viral dynamics-host interactions of IBV vaccination in chickens to gain major insights into the virus biology and host responses that will aid in developing better vaccines and control strategies.
What we do
Through application of gold standard virological assays; advanced light microscopy; and high throughput sequencing methodologies, we aim to characterise a set of pathogenic (disease-causing) and attenuated (non-disease-causing) vaccine viruses to identify those markers that play a role in making better coronavirus vaccines for poultry. With the help of state-of-art spatial transcriptomic technology, we dig deep into the attenuation process and look for the underpinning molecular interactions between IBV and its host. In addition, we will use deep machine learning algorithms to integrate data analysis and make predictions to identify markers that cause severe disease in birds.
